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PB-22 and 5F-PB-22 were the initial synthetic cannabinoids to incorporate a quinoline substructure and an ester linkage. These compounds are thought to happen to be synthesized Together with the intention of creating a synthetic cannabinoid prodrug, which could enhance absorption and confound detection. Ester bonds are effortlessly biodegradable as a result of spontaneous or endogenous, nonspecific esterase hydrolysis, which has been normally used in medicinal chemistry to produce ester prodrugs.
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